منابع مشابه
Organizing multivalency in carbohydrate recognition.
The interactions of cell surface carbohydrates as well as of soluble glycoconjugates with their receptor proteins rule fundamental processes in cell biology. One of the supramolecular principles underlying and regulating carbohydrate recognition is multivalency. Many multivalent glycoconjugates have therefore been synthesized to study multivalency effects operative in glycobiology. This review ...
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The immune system is a complex functional network of diverse cells and soluble molecules orchestrating innate and adaptive immunity. Biological information, to run these intricate interactions, is not only stored in protein sequences but also in the structure of the glycan part of the glycoconjugates. The spatially accessible carbohydrate structures that contribute to the cell's glycome are dec...
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Specific interaction between specific carbohydrate moieties of glycosphingolipids (GSLs) has been demonstrated based on interaction of GSLcontaining liposomes with GSL-coated solid phase, and affinity adsorption of multivalent GSL oligosaccharide on solid-phase GSL column. Evidence is presented that such GSL-GSL interaction is an initial step in the cell recognition process. Examples are LeX-Le...
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Carbohydrate recognition is a phenomenon critical to a number of biological functions in humans including highly specific responses of the immune system and the selective synthesis of functional proteins. Unlike polypeptides and proteins, oligosaccharides have been observed to have dynamic properties with extensive ability to occupy different conformations over time and space. Understanding the...
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Many carbohydrate-binding proteins contain aromatic amino acid residues in their binding sites. These residues interact with carbohydrates in a stacking geometry via CH/π interactions. These interactions can be found in carbohydrate-binding proteins, including lectins, enzymes and carbohydrate transporters. Besides this, many non-protein aromatic molecules (natural as well as artificial) can bi...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2015
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.3109